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DeCS
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Descriptor English:
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Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
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Descriptor Spanish:
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Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina
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Descriptor Portuguese:
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Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina
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Synonyms English:
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Dardarin Protein
LRRK2 Protein
PARK8 Protein
Leucine Rich Repeat Serine Threonine Protein Kinase 2
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Tree Number:
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D08.811.913.696.620.682.700.534
D12.776.637.750
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Definition English:
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A serine/threonine protein kinase with GTPase activity that contains 12 LEUCINE-rich repeats in its central region and 7 WD repeats C-terminal to its kinase and GTPase domains. It localizes to TRANSPORT VESICLES; the OUTER MITOCHONDRIAL MEMBRANE; and the GOLGI APPARATUS. It functions in PROTEIN TRANSPORT; regulates neuron morphology in the central nervous system, and also functions in the trafficking of SYNAPTIC VESICLES. Mutations in the LRRK2 gene have been identified in autosomal dominant cases of PARKINSON DISEASE (PARK8). |
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History Note English:
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2017
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Allowable Qualifiers English:
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Record Number:
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56511
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Unique Identifier:
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D000071158
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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